Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CIT | O14578 | 2/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | DUSP10 | Q9Y6W6 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | MC5R | P33032 | 1/20 | 0.34 |
| ▸ | MC3R | P41968 | 1/20 | 0.34 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.34 |
| ▸ | TPH1 | P17752 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NPR3 | P17342 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4519488 | 0.91 | MAP4K4 (0.36) | CITPAX8CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4530316 | 0.90 | TPH1 (0.39) | CITTPH1GPR142 | |
| SCHEMBL4529959 | 0.83 | PAX8 (0.37) | CITPAX8SLC7A5F11DUSP10 | |
| SCHEMBL5961037 | 0.82 | SLC7A5 (0.47) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL5961039 | 0.82 | SLC7A5 (0.47) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL27509941 | 0.82 | SLC7A5 (0.47) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL4528517 | 0.80 | SLC7A5 (0.43) | CITSLC7A5ALPIPKMPTGS1 | |
| SCHEMBL4514247 | 0.78 | CIT (0.45) | CITSLC7A5MC4RMC5RMC3R | |
| SCHEMBL4516346 | 0.76 | SYK (0.36) | PAX8DUSP10PKMCYP3A4 | |
| SCHEMBL4529962 | 0.76 | HDAC8 (0.52) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ROCK1, ROCK2, RHOA | CIT 7/4885PAX8 3961/4885SLC7A5 3265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.