Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | RECQL | P46063 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP5 | P45974 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535423 | 0.96 | GAA (0.52) | ALDH1A1RECQLGAATSHRTP53 | |
| SCHEMBL4539523 | 0.89 | ALDH1A1 (0.50) | ALDH1A1RECQLGAATSHRTP53 | |
| SCHEMBL4531162 | 0.89 | KMT2A (0.45) | ALDH1A1LMNAKMT2AKDM4EUSP5 | |
| SCHEMBL4535273 | 0.89 | HTT (0.51) | ALDH1A1GAALMNAKMT2APOLB | |
| SCHEMBL4541337 | 0.89 | CYP3A4 (0.55) | ALDH1A1GAATP53MAPTEPHX2 | |
| SCHEMBL4542832 | 0.89 | ALDH1A1 (0.54) | ALDH1A1GAALMNAHPGDEPHX2 | |
| SCHEMBL4530586 | 0.88 | EPHX2 (0.52) | ALDH1A1TSHRMAPTEPHX2KMT2A | |
| SCHEMBL4539073 | 0.86 | EPHX2 (0.51) | ALDH1A1RECQLLMNAMAPTEPHX2 | |
| SCHEMBL4542103 | 0.86 | EPHX2 (0.51) | ALDH1A1GAAMAPTEPHX2USP5 | |
| SCHEMBL4537967 | 0.85 | ALDH1A1 (0.50) | ALDH1A1RECQLGAATSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |