Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | USP5 | P45974 | 1/20 | 0.46 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541028 | 0.96 | MEN1 (0.52) | HTTSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL4541778 | 0.93 | LMNA (0.58) | HTTSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL4542557 | 0.89 | TGM2 (0.47) | HTTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL4541337 | 0.89 | CYP3A4 (0.55) | SMN1; SMN2KDM4EALDH1A1POLBMEN1 | |
| SCHEMBL4531162 | 0.89 | KMT2A (0.45) | HTTSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL4532819 | 0.89 | ALDH1A1 (0.49) | LMNAKDM4EALDH1A1POLBKMT2A | |
| SCHEMBL4542832 | 0.89 | ALDH1A1 (0.54) | SMN1; SMN2LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL4535854 | 0.88 | KMT2A (0.47) | HTTSMN1; SMN2LMNAALDH1A1MEN1 | |
| SCHEMBL4539073 | 0.86 | EPHX2 (0.51) | HTTSMN1; SMN2LMNAALDH1A1POLB | |
| SCHEMBL4542103 | 0.86 | EPHX2 (0.51) | SMN1; SMN2ALDH1A1USP5CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |