Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | USP5 | P45974 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537743 | 0.96 | EPHX2 (0.48) | EPHX2KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4541164 | 0.94 | EPHX2 (0.56) | EPHX2KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4541252 | 0.90 | EPHX2 (0.50) | EPHX2KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4543003 | 0.88 | CNR1 (0.48) | KMT2AMEN1ALDH1A1SMN1; SMN2USP5 | |
| SCHEMBL4535854 | 0.88 | KMT2A (0.47) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4532819 | 0.88 | ALDH1A1 (0.49) | EPHX2KMT2AALDH1A1USP5MAPT | |
| SCHEMBL4534333 | 0.87 | PKM (0.50) | KMT2AALDH1A1SMN1; SMN2USP5MAPT | |
| SCHEMBL4542832 | 0.87 | ALDH1A1 (0.54) | EPHX2KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4537525 | 0.86 | EPHX2 (0.50) | EPHX2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL4539847 | 0.85 | USP30 (0.44) | MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |