Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DDIT3 | P35638 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539837 | 0.89 | MEN1 (0.55) | EPHX2ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL4541337 | 0.86 | CYP3A4 (0.55) | EPHX2ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL4532819 | 0.86 | ALDH1A1 (0.49) | EPHX2ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL4535273 | 0.86 | HTT (0.51) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4531162 | 0.86 | KMT2A (0.45) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL4542832 | 0.86 | ALDH1A1 (0.54) | EPHX2ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4542251 | 0.85 | NPBWR1 (0.54) | ALDH1A1MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4542103 | 0.84 | EPHX2 (0.51) | EPHX2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4535775 | 0.82 | CYP3A4 (0.61) | ALDH1A1MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4535423 | 0.82 | GAA (0.52) | ALDH1A1MAPTKMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |