Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 8/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555431 | 0.84 | DYRK1A (0.51) | ENPP2ESR1ESR2HSP90AA1HSP90AB1 | |
| SCHEMBL16431700 | 0.79 | ENPP2 (0.48) | ENPP2ESR1ESR2HSP90AA1ALDH1A1 | |
| SCHEMBL8404501 | 0.79 | DYRK1A (0.42) | DYRK1AALDH1A1HSD17B10KDM4ELMNA | |
| SCHEMBL21596940 | 0.76 | ENPP2 (0.45) | ENPP2ESR1ESR2HSP90AA1ALDH1A1 | |
| SCHEMBL18822704 | 0.76 | DYRK1A (0.40) | DYRK1A | |
| SCHEMBL14353775 | 0.76 | MPO (0.41) | DYRK1AALDH1A1ALOX15KDM4ELMNA | |
| SCHEMBL24943958 | 0.73 | DYRK1A (0.38) | DYRK1AALDH1A1HSD17B10ALOX15LMNA | |
| SCHEMBL6818471 | 0.72 | ENPP2 (0.41) | ENPP2ESR1ESR2HSP90AA1ALDH1A1 | |
| SCHEMBL17437927 | 0.71 | CA12 (0.44) | ENPP2ESR2ALDH1A1HSD17B10KDM4E | |
| SCHEMBL1423001 | 0.70 | GPR3 (0.46) | DYRK1AALDH1A1HSD17B10ALOX15LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638008-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012063207-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-05-18 | — | — | WO | disclosed |