Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533110 | 0.94 | HPGD (0.46) | EPHX2P2RX7HPGDCNR1CNR2 | |
| SCHEMBL4542865 | 0.89 | HPGD (0.43) | EPHX2P2RX7HPGDCNR1CNR2 | |
| SCHEMBL4542824 | 0.88 | HDAC3 (0.52) | EPHX2P2RX7HPGDALDH1A1L3MBTL1 | |
| SCHEMBL8061058 | 0.87 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL8059951 | 0.85 | EPHX2 (0.60) | EPHX2EPHX1 | |
| SCHEMBL4533513 | 0.85 | EPHX2 (0.60) | EPHX2EPHX1 | |
| SCHEMBL8064755 | 0.85 | KMT2A (0.51) | ALDH1A1L3MBTL1LMNAGAASMN1; SMN2 | |
| SCHEMBL4541037 | 0.84 | ALDH1A1 (0.61) | EPHX2HPGDALDH1A1L3MBTL1LMNA | |
| SCHEMBL4539753 | 0.83 | HDAC3 (0.49) | EPHX2P2RX7HPGDALDH1A1LMNA | |
| SCHEMBL4537324 | 0.82 | MEN1 (0.47) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |