Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 2/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543065 | 0.95 | EPHX2 (0.48) | HTTNPSR1TSHRLMNAALOX12 | |
| SCHEMBL8063498 | 0.91 | POLB (0.39) | HTTNPSR1TSHRLMNAALOX12 | |
| SCHEMBL4533128 | 0.90 | EPHX1 (0.51) | HTTNPSR1TSHRLMNAALOX12 | |
| SCHEMBL4539701 | 0.89 | HDAC3 (0.47) | HTTNPSR1TSHRLMNAALOX12 | |
| SCHEMBL4535087 | 0.87 | EPHX1 (0.49) | HTTNPSR1TSHRLMNAALOX12 | |
| SCHEMBL4537343 | 0.87 | LMNA (0.59) | HTTNPSR1TSHRLMNAALOX12 | |
| SCHEMBL4539317 | 0.85 | HSD11B1 (0.49) | HTTNPSR1TSHRLMNAALOX12 | |
| SCHEMBL4540405 | 0.84 | HSD11B1 (0.56) | EPHX2EPHX1 | |
| SCHEMBL4535493 | 0.84 | HDAC3 (0.52) | HTTNPSR1TSHRLMNAALOX12 | |
| SCHEMBL8070996 | 0.84 | HDAC3 (0.52) | HTTNPSR1TSHRLMNAALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |