Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533522 | 0.97 | KMT2A (0.44) | MEN1KMT2AL3MBTL1RAB9ANPC1 | |
| SCHEMBL8058698 | 0.97 | KMT2A (0.44) | MEN1KMT2AL3MBTL1RAB9ANPC1 | |
| SCHEMBL4542459 | 0.88 | P2RX7 (0.42) | — | |
| SCHEMBL4539750 | 0.87 | HSD11B1 (0.52) | — | |
| SCHEMBL4530191 | 0.86 | EPHX2 (0.50) | RAB9ANPC1 | |
| SCHEMBL4541859 | 0.85 | RAB9A (0.54) | RAB9A | |
| SCHEMBL4531364 | 0.85 | HSD11B1 (0.44) | KMT2A | |
| SCHEMBL4541154 | 0.84 | RAB9A (0.56) | RAB9A | |
| SCHEMBL4537337 | 0.83 | ATM (0.46) | KMT2ARAB9A | |
| SCHEMBL4537565 | 0.82 | RAB9A (0.51) | RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |