Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | USP5 | P45974 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533116 | 0.94 | EPHX2 (0.50) | EPHX2ALDH1A1RAB9AHTR7L3MBTL1 | |
| SCHEMBL4542868 | 0.90 | EPHX2 (0.46) | EPHX2ALDH1A1RAB9AHTR7L3MBTL1 | |
| SCHEMBL4542825 | 0.88 | HDAC3 (0.53) | EPHX2ALDH1A1L3MBTL1USP5KMT2A | |
| SCHEMBL4533514 | 0.85 | ALDH1A1 (0.53) | EPHX2ALDH1A1L3MBTL1CNR2MEN1 | |
| SCHEMBL4541041 | 0.84 | ALDH1A1 (0.62) | EPHX2ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL4539756 | 0.83 | HDAC3 (0.50) | EPHX2ALDH1A1KMT2AMMP2MMP13 | |
| SCHEMBL4537325 | 0.83 | MEN1 (0.51) | RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL4533525 | 0.82 | KMT2A (0.48) | EPHX2ALDH1A1RAB9AL3MBTL1MEN1 | |
| SCHEMBL4541164 | 0.81 | EPHX2 (0.56) | EPHX2ALDH1A1L3MBTL1USP5MEN1 | |
| SCHEMBL4533158 | 0.80 | EPHX2 (0.48) | EPHX2ALDH1A1L3MBTL1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |