Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 5/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | USP5 | P45974 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8060988 | 1.00 | PKM (0.49) | PKMCHRM5P2RX2POLBALDH1A1 | |
| SCHEMBL8048322 | 0.88 | ALDH1A1 (0.45) | PKMPOLBALDH1A1LMNAHPGD | |
| SCHEMBL4530583 | 0.88 | EPHX2 (0.46) | POLBALDH1A1LMNAHPGDUSP2 | |
| SCHEMBL4543002 | 0.88 | ALDH1A1 (0.45) | PKMPOLBALDH1A1LMNAHPGD | |
| SCHEMBL4539990 | 0.87 | USP2 (0.56) | PKMPOLBALDH1A1LMNAUSP2 | |
| SCHEMBL8053633 | 0.87 | ALDH1A1 (0.43) | PKMPOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4535853 | 0.86 | FBP1 (0.46) | ALDH1A1LMNASMN1; SMN2HPGDKMT2A | |
| SCHEMBL4542831 | 0.85 | ALDH1A1 (0.53) | PKMALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL4541158 | 0.84 | ALDH1A1 (0.49) | POLBALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL4541786 | 0.84 | NPC1 (0.55) | POLBALDH1A1LMNASMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |