Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | USP5 | P45974 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537741 | 0.95 | EPHX2 (0.44) | EPHX2ALDH1A1GAAPOLBLMNA | |
| SCHEMBL4541162 | 0.94 | EPHX2 (0.50) | EPHX2ALDH1A1GAAPOLBUSP2 | |
| SCHEMBL4541251 | 0.90 | EPHX2 (0.45) | EPHX2ALDH1A1GAAPOLBUSP2 | |
| SCHEMBL8053633 | 0.89 | ALDH1A1 (0.43) | ALDH1A1GAAPOLBUSP2LMNA | |
| SCHEMBL4535853 | 0.88 | FBP1 (0.46) | ALDH1A1LMNAMEN1KMT2AHPGD | |
| SCHEMBL8048322 | 0.88 | ALDH1A1 (0.45) | ALDH1A1GAAPOLBUSP2LMNA | |
| SCHEMBL4543002 | 0.88 | ALDH1A1 (0.45) | ALDH1A1GAAPOLBUSP2LMNA | |
| SCHEMBL4532816 | 0.88 | TP53 (0.48) | ALDH1A1GAAPOLBLMNAMEN1 | |
| SCHEMBL4542831 | 0.88 | ALDH1A1 (0.53) | EPHX2ALDH1A1GAALMNAMEN1 | |
| SCHEMBL4534329 | 0.88 | PKM (0.49) | ALDH1A1POLBUSP2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |