Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.47 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538143 | 0.97 | RAB9A (0.50) | RAB9AHCRTR1HCRTR2BDKRB1ITGB1 | |
| SCHEMBL4542142 | 0.90 | HTR7 (0.46) | RAB9AHCRTR1HCRTR2BDKRB1HTR6 | |
| SCHEMBL4533331 | 0.88 | HTR1A (0.56) | RAB9A | |
| SCHEMBL4539544 | 0.88 | RAB9A (0.53) | RAB9A | |
| SCHEMBL4542334 | 0.88 | PSEN1 (0.53) | RAB9A | |
| SCHEMBL4538792 | 0.88 | PSEN1 (0.53) | RAB9A | |
| SCHEMBL4541860 | 0.87 | RAB9A (0.61) | RAB9A | |
| SCHEMBL4541044 | 0.87 | CNR1 (0.45) | RAB9AITGB1ITGA4ITGB7 | |
| SCHEMBL4542338 | 0.86 | HCRTR1 (0.48) | RAB9AHCRTR1HCRTR2BDKRB1ITGB1 | |
| SCHEMBL4530970 | 0.86 | HTR7 (0.52) | RAB9AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |