Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.45 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538143 | 0.90 | RAB9A (0.50) | ITGB1ITGA4ITGB7RAB9APSEN1 | |
| SCHEMBL4535937 | 0.89 | PSEN1 (0.58) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4535237 | 0.87 | RAB9A (0.53) | ITGB1ITGA4ITGB7RAB9A | |
| SCHEMBL4542597 | 0.86 | MAPT (0.45) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4542334 | 0.86 | PSEN1 (0.53) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4538792 | 0.86 | PSEN1 (0.53) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4537065 | 0.85 | TSHR (0.44) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4537566 | 0.85 | RAB9A (0.57) | RAB9A | |
| SCHEMBL4537228 | 0.84 | POLB (0.41) | RAB9APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4539055 | 0.83 | RAB9A (0.46) | RAB9APSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |