Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541156 | 0.97 | RAB9A (0.58) | RAB9APAX8 | |
| SCHEMBL4535937 | 0.89 | PSEN1 (0.58) | RAB9APAX8ALDH1A1PSEN1PSEN2 | |
| SCHEMBL4536845 | 0.89 | RAB9A (0.52) | RAB9ATSHR | |
| SCHEMBL4539055 | 0.89 | RAB9A (0.46) | RAB9APAX8TP53TSHRPSEN1 | |
| SCHEMBL4537566 | 0.89 | RAB9A (0.57) | RAB9AALDH1A1 | |
| SCHEMBL4534822 | 0.88 | MEN1 (0.52) | RAB9APAX8ALDH1A1TSHR | |
| SCHEMBL4536852 | 0.88 | HTR1A (0.52) | RAB9A | |
| SCHEMBL4537480 | 0.86 | NCOA1 (0.54) | RAB9APAX8NCOA1NCOA3GAA | |
| SCHEMBL4538792 | 0.86 | PSEN1 (0.53) | RAB9APAX8PSEN1PSEN2APH1B | |
| SCHEMBL4542334 | 0.86 | PSEN1 (0.53) | RAB9APAX8PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |