Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 5/20 | 0.58 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.58 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.58 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.58 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.58 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542334 | 0.97 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4538792 | 0.97 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4541044 | 0.89 | CNR1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4539055 | 0.89 | RAB9A (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4536845 | 0.89 | RAB9A (0.52) | MAPTRAB9A | |
| SCHEMBL4535259 | 0.89 | RAB9A (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4537566 | 0.89 | RAB9A (0.57) | ALDH1A1RAB9A | |
| SCHEMBL4542597 | 0.88 | MAPT (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4538143 | 0.88 | RAB9A (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4537065 | 0.87 | TSHR (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |