Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MYOC | Q99972 | 1/20 | 0.37 |
| ▸ | SGK1 | O00141 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3573967 | 0.72 | MAPT (0.66) | ATMMAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL25490115 | 0.71 | MEN1 (0.56) | ATMMAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL4535523 | 0.70 | KMT2A (0.47) | ATMMAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL4631425 | 0.69 | ALDH1A1 (0.56) | ATMMAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL14601827 | 0.69 | MAPT (0.57) | ATMMAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL6261538 | 0.69 | MAPT (0.62) | ATMMAPTKMT2ASMN1; SMN2NPC1 | |
| 4-Nitrophenyl Phenylcarbamate SCHEMBL1434931 | 0.69 | ALDH1A1 (0.62) | ATMMAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL4183001 | 0.69 | MAPT (0.57) | ATMMAPTKMT2ASMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL4182996 | 0.68 | MAPT (0.56) | ATMMAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8776629 | 0.68 | MAPT (0.59) | ATMMAPTKMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ROCK1, ROCK2, RHOA | ATM 881/4885AURKA 286/4885MAPT 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.