Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.43 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.43 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7042249 | 0.93 | MAOA (0.40) | MAOAMAOBIDO1CDC25BAKT1 | |
| SCHEMBL50865 | 0.92 | MAOA (0.50) | MAOAMAOBIDO1CDC25BAKT1 | |
| SCHEMBL30252635 | 0.92 | MAOA (0.50) | MAOAMAOBIDO1CDC25BAKT1 | |
| Hydrochloric Acid SCHEMBL30537100 | 0.90 | MAOA (0.48) | MAOAMAOBIDO1CDC25BAKT1 | |
| Hydrochloric Acid SCHEMBL2710069 | 0.90 | MAOA (0.48) | MAOAMAOBIDO1CDC25BAKT1 | |
| Hydrochlorthiazide SCHEMBL6010085 | 0.74 | CDC25B (0.33) | MAOAMAOBIDO1CDC25BAKT1 | |
| Indene SCHEMBL30959780 | 0.74 | CA2 (0.47) | MAOAMAOBCES1SRD5A2SRD5A1 | |
| Indene SCHEMBL6700608 | 0.74 | CA2 (0.47) | MAOAMAOBCES1SRD5A2SRD5A1 | |
| SCHEMBL9639127 | 0.73 | SRD5A2 (0.47) | SRD5A2SRD5A1KDM4EALDH1A1TDP1 | |
| SCHEMBL1279159 | 0.73 | SRD5A2 (0.37) | SMN1; SMN2SRD5A2SRD5A1KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069472-A1 | ANTISTATIC AGENTS FOR RESINS, ANTISTATIC RESIN COMPOSITIONS, AND ANTISTATIC RESIN MOLDED PRODUCTS | NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) | 2009-03-12 | — | — | US | disclosed |
| EP-1574548-B1 | ANTISTATIC AGENTS FOR RESINS, ANTISTATIC RESIN COMPOSITIONS, AND MOLDINGS OF ANTISTATIC RESINS | NIPPON CHEMICAL IND (JP) | 2008-04-16 | — | — | EP | disclosed |
| US-20060100326-A1 | Antistatic agents for resins, antistatic resin compositions, and molding of antistatic resins | NIPPPON CHEMICAL INDUSTRIAL CO., LTD (JP) | 2006-05-11 | — | — | US | disclosed |
| EP-1574548-A1 | ANTISTATIC AGENTS FOR RESINS, ANTISTATIC RESIN COMPOSITIONS, AND MOLDINGS OF ANTISTATIC RESINS | Nippon Chemical Industrial Co., Ltd. (JP) | 2005-09-14 | — | — | EP | disclosed |