Hydrochlorthiazide

Hydrochlorthiazide

SCHEMBL6010085

O=C1C=CCc2ccccc21.c1cscn1

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CDC25B P30305 2/20 0.33
MAOA P21397 2/20 0.33
IDO1 P14902 1/20 0.33
MAOB P27338 1/20 0.33
AKT1 P31749 1/20 0.33
SNCA P37840 1/20 0.33
MAP2K1 Q02750 1/20 0.33
PIN1 Q13526 1/20 0.33
EHMT2 Q96KQ7 1/20 0.33
NSD1 Q96L73 1/20 0.33
EHMT1 Q9H9B1 1/20 0.33
CA12 O43570 1/20 0.31
CA9 Q16790 1/20 0.31
ACHE P22303 1/20 0.31
CYP19A1 P11511 4/20 0.31
PFKFB3 Q16875 1/20 0.30
S100A4 P26447 1/20 0.30
CES1 P23141 1/20 0.30
TNF P01375 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Naphthoquinone SCHEMBL27590385 0.81 CDC25B (0.54) CDC25BMAOAIDO1MAOBAKT1
SCHEMBL50865 0.80 MAOA (0.50) CDC25BMAOAIDO1MAOBAKT1
SCHEMBL30252635 0.80 MAOA (0.50) CDC25BMAOAIDO1MAOBAKT1
Hydrochloric Acid SCHEMBL30537100 0.79 MAOA (0.48) CDC25BMAOAIDO1MAOBAKT1
Hydrochloric Acid SCHEMBL2710069 0.79 MAOA (0.48) CDC25BMAOAIDO1MAOBAKT1
Anthrone SCHEMBL11500970 0.75 MAOA (0.60) MAOAMAOBACHECYP19A1CES1
Bicarbonate SCHEMBL4535593 0.74 MAOA (0.43) CDC25BMAOAIDO1MAOBAKT1
Anthraquinone SCHEMBL11057931 0.73 MAOA (0.50) CDC25BMAOAIDO1MAOBS100A4
Anthraquinone SCHEMBL10486063 0.73 MAOA (0.50) CDC25BMAOAIDO1MAOBS100A4
Fluorene SCHEMBL28304242 0.73 MAOA (0.41) MAOAMAP2K1CYP19A1CES1TNF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7022721-B1 Method and composition for rejuvenating cells, tissues, organs, hair and nails ULRICH PETER C 2006-04-04 US disclosed
EP-1368029-A4 METHOD AND COMPOSITION FOR REJUVINATING CELLS, TISSUES, ORGANS, HAIR AND NAILS FARRINGTON PHARMACEUTICALS LLC (US) 2006-02-15 EP disclosed
US-20050245512-A1 Method and composition for rejuvinating cells, tissues organs, hair and nails ULRICH PETER C 2005-11-03 US disclosed
US-6777557-B2 Method and composition for rejuvenating cells, tissues organs, hair and nails FARRINGTON PHARMACEUTICALS, LLC 2004-08-17 US disclosed
US-6689777-B2 DEPOLYMERIZING HEMOZOIN USING 2-IMINO-NAPHTHO(1,2-D)THIAZOL-5-OL DERIVATIVES KENNETH S. WARREN INSTITUTE 2004-02-10 US disclosed
EP-1368029-A2 METHOD AND COMPOSITION FOR REJUVINATING CELLS, TISSUES, ORGANS, HAIR AND NAILS Farrington Pharmaceuticals, LLC (US) 2003-12-10 EP disclosed
US-20030186993-A1 Anti-malarial compounds, compositions and methods KENNETH S. WARREN INSTITUTE 2003-10-02 US disclosed
US-20020188015-A1 Method and composition for rejuvinating cells, tissues organs, hair and nails FARRINGTON PHARMACEUTICALS, LLC 2002-12-12 US disclosed
WO-2002062301-A2 METHOD AND COMPOSITION FOR REJUVINATING CELLS, TISSUES, ORGANS, HAIR AND NAILS FARRINGTON PHARMACEUTICALS, LLC (US) 2002-08-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020188015-A1 Method and composition for rejuvinating cells, tissues organs, hair and nails TERT, TELO2, HKDC1 CDC25B 2989/4885MAOA 4393/4885IDO1 1062/4885
US-20050245512-A1 Method and composition for rejuvinating cells, tissues organs, hair and nails TERT, TELO2, HKDC1 CDC25B 2989/4885MAOA 4393/4885IDO1 1062/4885
US-20030186993-A1 Anti-malarial compounds, compositions and methods TYR, CRYZ, RHOT2 CDC25B 1043/4885MAOA 1895/4885IDO1 2123/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.