SCHEMBL4535774

SCHEMBL4535774

O=C(NCC1CCCN(S(=O)(=O)c2ccc(F)cc2)C1)C12CC3CC(CC(C3)C1)C2

nearest known ligand 0.59

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.59
CYP2C19 P33261 1/20 0.59
MAPT P10636 1/20 0.51
KMT2A Q03164 3/20 0.49
TP53 P04637 1/20 0.48
CYP19A1 P11511 1/20 0.48
MEN1 O00255 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
NAMPT P43490 1/20 0.48
ALDH1A1 P00352 3/20 0.46
GLA P06280 1/20 0.45
DPP4 P27487 1/20 0.45
LMNA P02545 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8066749 0.95 CYP3A4 (0.51) CYP3A4CYP2C19MAPTKMT2ATP53
SCHEMBL4541335 0.95 CYP3A4 (0.51) CYP3A4CYP2C19MAPTKMT2ATP53
SCHEMBL4535419 0.90 KMT2A (0.49) CYP3A4CYP2C19KMT2ATP53SMN1; SMN2
SCHEMBL4541025 0.90 MEN1 (0.50) CYP3A4CYP2C19KMT2AMEN1SMN1; SMN2
SCHEMBL4535499 0.89 ALDH1A1 (0.56) KMT2ATP53NAMPTALDH1A1
SCHEMBL4541786 0.87 NPC1 (0.55) MAPTSMN1; SMN2ALDH1A1LMNA
SCHEMBL4542921 0.86 CYP3A4 (0.57) CYP3A4CYP2C19MAPTKMT2ACYP19A1
SCHEMBL8064991 0.85 ALDH1A1 (0.49) KMT2ACYP19A1MEN1ALDH1A1LMNA
SCHEMBL4534658 0.85 CYP3A4 (0.49) CYP3A4CYP2C19MAPTKMT2ATP53
SCHEMBL8061563 0.85 LMNA (0.51) KMT2AMEN1SMN1; SMN2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009070497-A1 SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE SMITHKLINE BEECHAM CORPORATION (US) 2009-06-04 WO claimed
WO-2009070497-A1 SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE SMITHKLINE BEECHAM CORPORATION (US) 2009-06-04 WO disclosed