Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | USP5 | P45974 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541335 | 0.94 | CYP3A4 (0.51) | ALDH1A1POLBTP53PKMKMT2A | |
| SCHEMBL8066749 | 0.94 | CYP3A4 (0.51) | ALDH1A1POLBTP53PKMKMT2A | |
| SCHEMBL4541776 | 0.89 | LMNA (0.55) | ALDH1A1POLBL3MBTL1KMT2AUSP5 | |
| SCHEMBL4541037 | 0.89 | ALDH1A1 (0.61) | ALDH1A1PKML3MBTL1KMT2AEPHX2 | |
| SCHEMBL4535774 | 0.89 | CYP3A4 (0.59) | ALDH1A1TP53KMT2ANAMPT | |
| SCHEMBL4542839 | 0.86 | PKM (0.56) | ALDH1A1PKMKMT2AUSP5EPHX2 | |
| SCHEMBL4534658 | 0.85 | CYP3A4 (0.49) | ALDH1A1POLBTP53PKMKMT2A | |
| SCHEMBL8064991 | 0.83 | ALDH1A1 (0.49) | ALDH1A1POLBL3MBTL1KMT2ACA12 | |
| SCHEMBL8061563 | 0.83 | LMNA (0.51) | ALDH1A1POLBKMT2AEPHX2KDM4E | |
| SCHEMBL4532816 | 0.83 | TP53 (0.48) | ALDH1A1POLBTP53PKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |