Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
| ▸ | GABRE | P78334 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29813789 | 1.00 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA7HTR3AAURKA | |
| SCHEMBL28901281 | 0.78 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNA7HTR3ACYP2C19 | |
| SCHEMBL28901276 | 0.78 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNA7HTR3ACYP2C19 | |
| SCHEMBL12649101 | 0.78 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNA7HTR3ACYP2C19 | |
| SCHEMBL7851250 | 0.72 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA7CHRM5CHRM3 | |
| SCHEMBL7842456 | 0.72 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA7CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL7842697 | 0.71 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNA7CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL7850658 | 0.71 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNA7CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL8177269 | 0.71 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNA7CHRM5CHRM3 | |
| SCHEMBL24473907 | 0.71 | NPC1 (0.43) | CHRNA7HTR3AGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318445-A1 | PDF INHIBITORS | NORVARTIS AG (CH) | 2009-12-24 | — | — | US | disclosed |
| EP-1973898-A1 | PDF INHIBITORS | Novartis AG (CH) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007077186-A1 | PDF INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318445-A1 | PDF INHIBITORS | PDF, TIMP3, MMP2 | CHRNB2 4884/4885CHRNA4 4881/4885CHRNA7 4885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.