Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4536379 | 0.87 | — | — | |
| SCHEMBL4536182 | 0.84 | GPR119 (0.45) | GPR119NPC1RAB9AKDM4EMAPT | |
| SCHEMBL4536702 | 0.80 | GPR119 (0.49) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL4358178 | 0.80 | GPR119 (0.51) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL4353381 | 0.79 | GPR119 (0.54) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL4559713 | 0.79 | MMP13 (0.43) | GPR119ALDH1A1KDM4EPTPN2PTPN1 | |
| SCHEMBL4353796 | 0.79 | GPR119 (0.55) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL13586038 | 0.78 | GPR119 (0.54) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL4353589 | 0.78 | PTPN2 (0.48) | GPR119NPC1RAB9AKDM4EPTPN2 | |
| SCHEMBL4360506 | 0.78 | GPR119 (0.47) | GPR119PTPN2PTPN1PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150144-A1 | NEW GPR119MODULATORS | INOVACIA AB (SE) | 2009-12-17 | — | — | WO | disclosed |
| WO-2009150144-A1 | NEW GPR119MODULATORS | INOVACIA AB (SE) | 2009-12-17 | — | — | WO | disclosed |