Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 9/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541405 | 0.95 | EPHX1 (0.62) | EPHX1ALDH1A1EPHX2HDAC3HDAC4 | |
| SCHEMBL19798447 | 0.76 | EPHX1 (0.71) | EPHX1ALDH1A1EPHX2HDAC3HDAC4 | |
| SCHEMBL4535957 | 0.74 | EPHX1 (1.00) | EPHX1ALDH1A1EPHX2HDAC3HDAC4 | |
| SCHEMBL6337057 | 0.74 | EPHX1 (0.47) | EPHX1ALDH1A1EPHX2MEN1KMT2A | |
| SCHEMBL5372949 | 0.73 | FDPS (0.46) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL4542363 | 0.72 | EPHX1 (1.00) | EPHX1ALDH1A1EPHX2HDAC3HDAC4 | |
| SCHEMBL4537511 | 0.72 | EPHX1 (0.84) | EPHX1ALDH1A1EPHX2HDAC3HDAC4 | |
| SCHEMBL6050265 | 0.70 | FDPS (0.44) | EPHX1ALDH1A1MAPTNPSR1MEN1 | |
| SCHEMBL28568718 | 0.70 | FDPS (0.50) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL24804995 | 0.69 | FDPS (0.53) | ALDH1A1MAPTNPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |