Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 8/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4827562 | 0.95 | EPHX1 (0.51) | EPHX1EPHX2MEN1KMT2ATSHR | |
| SCHEMBL17437543 | 0.95 | EPHX1 (0.51) | EPHX1EPHX2MEN1KMT2ATSHR | |
| SCHEMBL5160032 | 0.95 | EPHX1 (0.51) | EPHX1EPHX2MEN1KMT2ATSHR | |
| SCHEMBL15994667 | 0.76 | EPHX2 (0.49) | EPHX2 | |
| SCHEMBL2638872 | 0.75 | EPHX2 (0.57) | EPHX1EPHX2MEN1KMT2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL9279520 | 0.75 | TSHR (0.56) | EPHX1EPHX2MEN1KMT2ATSHR | |
| Hydrochloric Acid SCHEMBL9279531 | 0.75 | TSHR (0.56) | EPHX1EPHX2MEN1KMT2ATSHR | |
| SCHEMBL2638571 | 0.74 | EPHX2 (0.59) | EPHX1EPHX2MEN1KMT2ASIGMAR1 | |
| SCHEMBL4536680 | 0.74 | EPHX1 (0.58) | EPHX1EPHX2MEN1KMT2AALDH1A1 | |
| SCHEMBL15962430 | 0.73 | PRCP (0.46) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261302-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application | ABBOTT LABORATORIES | 2005-11-24 | — | — | US | disclosed |
| US-20050245533-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenaseType 1 enzyme and their therapeutic application | ABBOTT LABORATORIES | 2005-11-03 | — | — | US | disclosed |
| US-20050245532-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application | ABBOTT LABORATORIES | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245532-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application | HSD11B1, HSD17B1, HSD3B1 | EPHX1 479/4885EPHX2 696/4885MEN1 2126/4885 |
| US-20050245533-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenaseType 1 enzyme and their therapeutic application | HSD11B1, HSD17B1, HSD3B1 | EPHX1 451/4885EPHX2 676/4885MEN1 2533/4885 |
| US-20050261302-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application | HSD11B1, HSD17B1, HSD3B1 | EPHX1 479/4885EPHX2 696/4885MEN1 2126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.