Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533525 | 0.85 | KMT2A (0.48) | RAB9AALDH1A1KMT2AMCOLN3 | |
| SCHEMBL4531367 | 0.85 | RAB9A (0.43) | RAB9AALDH1A1KMT2AMCOLN3OPRM1 | |
| SCHEMBL4537337 | 0.84 | ATM (0.46) | ATMRAB9AALDH1A1KMT2AMCOLN3 | |
| SCHEMBL4537566 | 0.83 | RAB9A (0.57) | RAB9AALDH1A1 | |
| SCHEMBL4537325 | 0.82 | MEN1 (0.51) | RAB9AKMT2A | |
| SCHEMBL4542462 | 0.82 | RAB9A (0.46) | RAB9A | |
| SCHEMBL4539751 | 0.82 | ATM (0.50) | ATMCTSLCTSBCTSKALDH1A1 | |
| SCHEMBL4538974 | 0.81 | CYP19A1 (0.39) | RAB9AKMT2A | |
| SCHEMBL4541860 | 0.79 | RAB9A (0.61) | RAB9A | |
| SCHEMBL4541692 | 0.78 | RAB9A (0.47) | RAB9AALDH1A1KMT2AMCOLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |