Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4536776 | 0.95 | LMNA (0.62) | LMNAHTTNPSR1TSHRALOX12 | |
| SCHEMBL4530361 | 0.90 | CYP3A4 (0.59) | LMNAHTTNPSR1TSHRALOX12 | |
| SCHEMBL4537575 | 0.90 | ALDH1A1 (0.49) | LMNAHTTNPSR1TSHRALOX12 | |
| SCHEMBL4537427 | 0.90 | SMN1; SMN2 (0.52) | LMNAHTTNPSR1TSHRALOX12 | |
| SCHEMBL4536605 | 0.89 | LMNA (0.67) | LMNAHTTNPSR1TSHRALOX12 | |
| SCHEMBL4539317 | 0.89 | HSD11B1 (0.49) | LMNAHTTNPSR1TSHRALOX12 | |
| SCHEMBL4539395 | 0.88 | LMNA (0.47) | LMNAHTTNPSR1TSHRALOX12 | |
| SCHEMBL4537319 | 0.87 | ALDH1A1 (0.52) | LMNAHTTNPSR1TSHREPHX1 | |
| SCHEMBL4537389 | 0.87 | HTT (0.46) | LMNAHTTNPSR1TSHRALOX12 | |
| SCHEMBL8060768 | 0.86 | LMNA (0.57) | LMNAHTTNPSR1TSHRALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |