SCHEMBL4537402

SCHEMBL4537402

Cc1cccc(Br)c1-c1c(C)cccc1Br

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.60
CYP2A6 P11509 2/20 0.43
CYP1A2 P05177 1/20 0.43
TSHR P16473 2/20 0.42
ACHE P22303 1/20 0.42
CD44 P16070 1/20 0.42
CA1 P00915 3/20 0.41
CA2 P00918 3/20 0.41
CA7 P43166 3/20 0.41
CA9 Q16790 3/20 0.41
PBRM1 Q86U86 1/20 0.41
CYP3A4 P08684 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
MAOA P21397 2/20 0.37
MAOB P27338 2/20 0.37
TRPA1 O75762 2/20 0.36
MAPK1 P28482 1/20 0.36
ATM Q13315 1/20 0.36
AHR P35869 1/20 0.36
MYC P01106 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10466534 0.86 TRPA1 (0.48) ALDH1A1CYP1A2TSHRCD44CA1
SCHEMBL27832336 0.83 ALDH1A1 (0.54) ALDH1A1TSHRACHEPBRM1TDP1
SCHEMBL10468391 0.83 ALDH1A1 (0.54) ALDH1A1TSHRACHECA1CA2
SCHEMBL1768477 0.83 ALDH1A1 (0.54) ALDH1A1TSHRACHECA1CA2
SCHEMBL28171115 0.79 ALDH1A1 (0.56) ALDH1A1CYP2A6CYP1A2TSHRACHE
SCHEMBL31264394 0.79 ALDH1A1 (0.56) ALDH1A1CYP2A6CYP1A2TSHRACHE
SCHEMBL29661770 0.79
SCHEMBL686929 0.79
SCHEMBL30978689 0.78
SCHEMBL286359 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2638126-A1 NEGATIVE DISPERSION RETARDATION PLATE AND ACHROMATIC CIRCULAR POLARIZER CRYSOPTIX K.K. (JP) 2013-09-18 EP disclosed
WO-2012064618-A1 NEGATIVE DISPERSION RETARDATION PLATE AND ACHROMATIC CIRCULAR POLARIZER CRYSOPTIX KK (JP) 2012-05-18 WO disclosed
EP-0408340-B1 Ruthenium-optically active phoshine complex useful as catalyst TAKASAGO PERFUMERY CO LTD (JP) 1996-01-24 EP disclosed
EP-0408338-B1 Catalytic production of carboxylic acids and esters thereof TAKASAGO PERFUMERY CO LTD (JP) 1995-09-27 EP disclosed
EP-0315886-B1 Isoquinoline derivatives, their manufacture and use HOFFMANN LA ROCHE (CH) 1995-02-15 EP disclosed
EP-0271311-B1 RUTHENIUM-PHOSPHINE COMPLEXES Takasago International Corporation (JP) 1993-02-17 EP disclosed
EP-0269395-B1 RUTHENIUM-PHOSPHINE COMPLEX CATALYSTS Takasago International Corporation (JP) 1993-02-17 EP disclosed
EP-0271310-B1 RUTHENIUM-PHOSPHINE COMPLEXES Takasago International Corporation (JP) 1993-02-03 EP disclosed
US-5087728-A Hydrogenating unsaturated compound using rhodium or ruthenium complex catalyst with specific diphosphine ligand TAKASAGO INTERNATIONAL CORPORATION (JP) 1992-02-11 US disclosed
US-5021593-A Used as hydrogenation, silylation or isomerization catalysts TAKASAGO INTERNATIONAL CORPORATION (JP) 1991-06-04 US disclosed
US-4857648-A Isoquinoline derivatives HOFFMANN-LA ROCHE INC. (US) 1989-08-15 US disclosed
US-4766227-A Ruthenium-phosphine complex TAKASAGO INTERNATIONAL CORPORATION (JP) 1988-08-23 US disclosed
US-4766225-A Ruthenium-phosphine complex TAKASAGO INTERNATIONAL CORPORATION (JP) 1988-08-23 US disclosed
US-4764629-A Ruthenium-phosphine complex TAKASAGO INTERNATIONAL CORPORATION (JP) 1988-08-16 US disclosed
EP-0104376-B1 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE AMINES AND ENAMINES F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1987-05-06 EP disclosed
EP-0104375-B1 PHOSPHORUS-CONTAINING BIPHENYL DERIVATIVES AND THEIR USE IN ASYMMETRIC HYDROGENATION AND ENATIOSELECTIVE HYDROGEN SHIFTS F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1986-10-15 EP disclosed
US-4578462-A Process for the manufacture of optically active compounds HOFFMANN-LA ROCHE INC. (US) 1986-03-25 US disclosed
US-4556740-A Phosphorus compounds HOFFMANN-LA ROCHE INC. (US) 1985-12-03 US disclosed
EP-0104376-A2 Process for the preparation of optically active amines and enamines F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1984-04-04 EP disclosed
EP-0104375-A1 Phosphorus-containing biphenyl derivatives and their use in asymmetric hydrogenation and enatioselective hydrogen shifts F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1984-04-04 EP disclosed