Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537553 | 0.90 | PAX8 (0.58) | RAB9ANPC1HTR7PAX8 | |
| SCHEMBL4537480 | 0.90 | NCOA1 (0.54) | RAB9ANPC1PAX8NCOA1NCOA3 | |
| SCHEMBL4535343 | 0.89 | HTR7 (0.50) | RAB9AHTR7ATMLMNATRPA1 | |
| SCHEMBL4536839 | 0.89 | BRD4 (0.56) | RAB9ANPC1HTR7PAX8NCOA1 | |
| SCHEMBL4536845 | 0.86 | RAB9A (0.52) | RAB9ANPC1HTR7MAPTTDP1 | |
| SCHEMBL4535468 | 0.82 | HTR7 (0.59) | RAB9ANPC1HTR7NCOA1NCOA3 | |
| SCHEMBL4542142 | 0.82 | HTR7 (0.46) | RAB9ANPC1HTR7PAX8SMN1; SMN2 | |
| SCHEMBL4537510 | 0.82 | RAB9A (0.56) | RAB9ANPC1HTR7MAPTTDP1 | |
| SCHEMBL4534659 | 0.81 | CYP3A4 (0.53) | MAPTSMN1; SMN2 | |
| SCHEMBL4531594 | 0.80 | TDP1 (0.42) | RAB9ANPC1HTR7TDP1PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |