Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537550 | 0.90 | PAX8 (0.56) | RAB9AHTR7PAX8LMNAALDH1A1 | |
| SCHEMBL4537477 | 0.90 | NCOA1 (0.53) | RAB9ANPC1PAX8NCOA1NCOA3 | |
| SCHEMBL4535339 | 0.90 | ATM (0.47) | RAB9AHTR7ATMPAX8LMNA | |
| SCHEMBL4536836 | 0.89 | BRD4 (0.55) | RAB9ANPC1PAX8NCOA1NCOA3 | |
| SCHEMBL4536842 | 0.87 | RAB9A (0.50) | RAB9ANPC1MAPTTDP1ATM | |
| SCHEMBL4535463 | 0.83 | HTR7 (0.55) | RAB9ANPC1HTR7NCOA1NCOA3 | |
| SCHEMBL4542139 | 0.83 | PAX8 (0.45) | RAB9ANPC1HTR7PAX8SMN1; SMN2 | |
| SCHEMBL4537513 | 0.82 | RAB9A (0.58) | RAB9ANPC1HTR7MAPTTDP1 | |
| SCHEMBL4534658 | 0.81 | CYP3A4 (0.49) | MAPTSMN1; SMN2ALDH1A1ENPP3CA12 | |
| SCHEMBL4531591 | 0.80 | DRD2 (0.42) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |