Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 7/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1529421 | 0.82 | HPGDS (0.43) | HPGDSHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL4544034 | 0.81 | HPGDS (0.38) | HPGDSHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL4543913 | 0.80 | HPGDS (0.36) | HPGDSHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL1529579 | 0.79 | HPGDS (0.41) | HPGDSHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL4382189 | 0.78 | ACKR3 (0.43) | HDAC1HDAC3HDAC4CTSL | |
| SCHEMBL4375386 | 0.78 | ACKR3 (0.43) | HDAC1HDAC3HDAC4CTSL | |
| SCHEMBL12679256 | 0.78 | ATM (0.45) | HPGDSCTSLDYRK1ADYRK1BCTSB | |
| SCHEMBL4592997 | 0.76 | AKT1 (0.43) | HPGDSAKT3DYRK1ADYRK1B | |
| SCHEMBL4542245 | 0.75 | AKT1 (0.39) | HDAC8CTSLCTSBCTSS | |
| SCHEMBL4378512 | 0.74 | AKT1 (0.40) | AKT3CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |