Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 5/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | TXK | P42681 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.35 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543913 | 0.81 | HPGDS (0.36) | HPGDSHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL1529412 | 0.81 | DYRK1A (0.43) | HPGDSGPR142HDAC1HDAC3HDAC4 | |
| SCHEMBL4537535 | 0.81 | HPGDS (0.41) | HPGDSHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL4382189 | 0.77 | ACKR3 (0.43) | HDAC1HDAC3HDAC4ACKR3 | |
| SCHEMBL4375386 | 0.77 | ACKR3 (0.43) | HDAC1HDAC3HDAC4ACKR3 | |
| SCHEMBL12679257 | 0.77 | ATM (0.45) | HPGDSGPR142PLK1DYRK1ADYRK1B | |
| SCHEMBL4378512 | 0.76 | AKT1 (0.40) | CCR1 | |
| SCHEMBL4542245 | 0.74 | AKT1 (0.39) | HDAC8 | |
| SCHEMBL4592997 | 0.73 | AKT1 (0.43) | HPGDSDYRK1ADYRK1B | |
| SCHEMBL4379225 | 0.73 | ANPEP (0.36) | HPGDSHDAC1HDAC3HDAC4DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |