Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 4/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539287 | 0.97 | HCRTR1 (0.48) | HCRTR1KCNQ1L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL4541277 | 0.86 | HSD11B1 (0.46) | KCNQ1KMT2AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4537814 | 0.86 | EPHX2 (0.44) | KMT2AALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8067220 | 0.85 | ALDH1A1 (0.54) | L3MBTL1KMT2AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4541031 | 0.85 | ALDH1A1 (0.54) | L3MBTL1KMT2AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4541739 | 0.84 | EPHX2 (0.48) | HCRTR1KMT2AALDH1A1MEN1EPHX1 | |
| SCHEMBL4537242 | 0.83 | NPC1 (0.53) | KMT2AALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4539776 | 0.83 | BRD4 (0.53) | ALDH1A1EPHX1BDKRB1 | |
| SCHEMBL4541290 | 0.83 | HSD11B1 (0.47) | KMT2AALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4541773 | 0.83 | EPHX2 (0.45) | HCRTR1KMT2AALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |