Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.53 |
| ▸ | BRD2 | P25440 | 4/20 | 0.53 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.49 |
| ▸ | BDKRB1 | P46663 | 10/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537833 | 0.89 | RAB9A (0.48) | EPHX1ALDH1A1LMNA | |
| SCHEMBL4535072 | 0.89 | BDKRB1 (0.56) | BDKRB1 | |
| SCHEMBL4540868 | 0.87 | BDKRB1 (0.49) | BDKRB1EPHX1ALDH1A1 | |
| SCHEMBL4541294 | 0.87 | PSEN1 (0.56) | BDKRB1EPHX1ALDH1A1LMNA | |
| SCHEMBL4537242 | 0.87 | NPC1 (0.53) | BDKRB1EPHX1ALDH1A1 | |
| SCHEMBL4535376 | 0.87 | BRD4 (0.54) | BRD4BRD2BRD3BRDTEPHX1 | |
| SCHEMBL4542153 | 0.86 | ALDH1A1 (0.47) | EPHX1ALDH1A1LMNA | |
| SCHEMBL4536790 | 0.86 | BDKRB1 (0.53) | BRD4BRD2BDKRB1 | |
| SCHEMBL4535199 | 0.85 | MMP1 (0.53) | BDKRB1 | |
| SCHEMBL4542928 | 0.84 | LMNA (0.55) | BDKRB1EPHX1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |