Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541773 | 0.97 | EPHX2 (0.45) | EPHX2EPHX1ALDH1A1KMT2AHSD11B1 | |
| SCHEMBL8049742 | 0.90 | EPHX2 (0.39) | EPHX2ALDH1A1KMT2AMCOLN3HSD11B1 | |
| SCHEMBL4541277 | 0.88 | HSD11B1 (0.46) | EPHX2EPHX1ALDH1A1KMT2AMCOLN3 | |
| SCHEMBL4534331 | 0.87 | HSD11B1 (0.57) | EPHX2EPHX1HSD11B1 | |
| SCHEMBL4537242 | 0.86 | NPC1 (0.53) | EPHX2EPHX1ALDH1A1KMT2AHSD11B1 | |
| SCHEMBL4537540 | 0.86 | HCRTR1 (0.46) | EPHX1ALDH1A1KMT2AMCOLN3HSD11B1 | |
| SCHEMBL4541290 | 0.85 | HSD11B1 (0.47) | EPHX2EPHX1ALDH1A1KMT2AHSD11B1 | |
| SCHEMBL8067220 | 0.85 | ALDH1A1 (0.54) | EPHX1ALDH1A1KMT2AHSD11B1NPC1 | |
| SCHEMBL4541031 | 0.85 | ALDH1A1 (0.54) | EPHX1ALDH1A1KMT2AHSD11B1NPC1 | |
| SCHEMBL4538162 | 0.85 | KMT2A (0.52) | EPHX2EPHX1ALDH1A1KMT2ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |