Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537385 | 0.96 | KMT2A (0.43) | POLBKMT2AF10EPHX2ALDH1A1 | |
| SCHEMBL4537039 | 0.91 | EPHX2 (0.47) | HTTKMT2AEPHX2ALDH1A1MEN1 | |
| SCHEMBL4538131 | 0.88 | HDAC3 (0.46) | POLBKMT2AEPHX2ALDH1A1 | |
| SCHEMBL4535088 | 0.87 | USP30 (0.47) | POLBTSHRHTTNPSR1KMT2A | |
| SCHEMBL4541028 | 0.86 | MEN1 (0.52) | POLBHTTNPSR1KMT2AALDH1A1 | |
| SCHEMBL4539370 | 0.85 | KMT2A (0.48) | POLBHTTKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL4539756 | 0.84 | HDAC3 (0.50) | KMT2AEPHX2ALDH1A1 | |
| SCHEMBL4531620 | 0.83 | HSD11B1 (0.58) | KMT2AEPHX2ALDH1A1MEN1 | |
| SCHEMBL4537312 | 0.83 | P2RX7 (0.43) | POLBTSHRHTTNPSR1KMT2A | |
| SCHEMBL4535939 | 0.83 | USP30 (0.48) | KMT2AEPHX2ALDH1A1L3MBTL1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |