Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541773 | 0.87 | EPHX2 (0.45) | KMT2ACNR2EPHX2ALDH1A1EPHX1 | |
| SCHEMBL4536688 | 0.85 | FKBP1A (0.51) | KMT2AMEN1CNR2FAAHLMNA | |
| SCHEMBL8067220 | 0.85 | ALDH1A1 (0.54) | KMT2APOLBALDH1A1HTR1AHTR7 | |
| SCHEMBL4541031 | 0.85 | ALDH1A1 (0.54) | KMT2APOLBALDH1A1HTR1AHTR7 | |
| SCHEMBL4541290 | 0.85 | HSD11B1 (0.47) | KMT2AFAAHLMNAHTTEPHX2 | |
| SCHEMBL4537814 | 0.85 | EPHX2 (0.44) | KMT2ACNR2EPHX2ALDH1A1EPHX1 | |
| SCHEMBL4542819 | 0.83 | RAB9A (0.54) | KMT2AEPHX2EPHX1 | |
| SCHEMBL4539287 | 0.83 | HCRTR1 (0.48) | KMT2AMEN1ALDH1A1EPHX1 | |
| SCHEMBL4541277 | 0.83 | HSD11B1 (0.46) | KMT2AFAAHLMNAHTTEPHX2 | |
| SCHEMBL4542205 | 0.83 | RAB9A (0.52) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |