Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535854 | 0.96 | KMT2A (0.47) | KMT2AALDH1A1MEN1LMNASMN1; SMN2 | |
| SCHEMBL4540835 | 0.91 | MEN1 (0.47) | KMT2AALDH1A1MEN1LMNASMN1; SMN2 | |
| SCHEMBL4542446 | 0.90 | SMN1; SMN2 (0.53) | KMT2AALDH1A1MEN1LMNASMN1; SMN2 | |
| SCHEMBL4537743 | 0.89 | EPHX2 (0.48) | KMT2AALDH1A1MEN1LMNASMN1; SMN2 | |
| SCHEMBL4541028 | 0.88 | MEN1 (0.52) | KMT2AALDH1A1MEN1LMNASMN1; SMN2 | |
| SCHEMBL4536853 | 0.87 | EPHX1 (0.49) | KMT2AALDH1A1MEN1LMNASMN1; SMN2 | |
| SCHEMBL4542881 | 0.86 | KMT2A (0.46) | KMT2AALDH1A1MEN1LMNAFBP1 | |
| SCHEMBL4537314 | 0.85 | POLB (0.44) | KMT2AALDH1A1MEN1HTTL3MBTL1 | |
| SCHEMBL4530586 | 0.84 | EPHX2 (0.52) | KMT2AALDH1A1MEN1SMN1; SMN2HTT | |
| SCHEMBL4543003 | 0.84 | CNR1 (0.48) | KMT2AALDH1A1MEN1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |