Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | FBP1 | P09467 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4540074 | 0.96 | FBP1 (0.50) | EPHX1EPHX2FBP1USP30ALDH1A1 | |
| SCHEMBL4542594 | 0.89 | MEN1 (0.47) | EPHX2ALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL4540008 | 0.89 | MEN1 (0.50) | ALDH1A1KMT2AMEN1L3MBTL1LMNA | |
| SCHEMBL4539370 | 0.87 | KMT2A (0.48) | FBP1ALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL4535088 | 0.85 | USP30 (0.47) | EPHX1EPHX2USP30ALDH1A1KMT2A | |
| SCHEMBL4537192 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1L3MBTL1MAPT | |
| SCHEMBL4537525 | 0.85 | EPHX2 (0.50) | EPHX2USP30ALDH1A1KMT2AMEN1 | |
| SCHEMBL4539044 | 0.84 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1L3MBTL1LMNA | |
| SCHEMBL4539885 | 0.83 | FAAH (0.45) | EPHX2ALDH1A1L3MBTL1POLBTP53 | |
| SCHEMBL4542338 | 0.83 | HCRTR1 (0.48) | EPHX1EPHX2FBP1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |