Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 12/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 11/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8067471 | 0.97 | EPHX1 (0.46) | EPHX1EPHX2LMNAHTTNPSR1 | |
| SCHEMBL4541718 | 0.97 | EPHX1 (0.46) | EPHX1EPHX2LMNAHTTNPSR1 | |
| SCHEMBL4534763 | 0.89 | EPHX1 (0.52) | EPHX1EPHX2 | |
| SCHEMBL4537224 | 0.87 | P2RX7 (0.43) | LMNAHTTNPSR1TSHRALOX12 | |
| SCHEMBL4540815 | 0.87 | HTT (0.44) | EPHX1EPHX2LMNAHTTNPSR1 | |
| SCHEMBL4539998 | 0.87 | LMNA (0.55) | EPHX1EPHX2LMNAHTTNPSR1 | |
| SCHEMBL4537063 | 0.86 | EPHX2 (0.52) | EPHX1EPHX2 | |
| SCHEMBL8067423 | 0.86 | EPHX2 (0.52) | EPHX1EPHX2 | |
| SCHEMBL4539341 | 0.85 | EPHX1 (0.48) | EPHX1EPHX2LMNAHTTNPSR1 | |
| SCHEMBL4530293 | 0.84 | P2RX7 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |