Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 8/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542335 | 0.97 | EPHX1 (0.48) | EPHX1EPHX2HSD11B1LMNAUSP2 | |
| SCHEMBL4542096 | 0.89 | HTR1A (0.47) | EPHX1EPHX2LMNAUSP2RAB9A | |
| SCHEMBL4539998 | 0.89 | LMNA (0.55) | EPHX1EPHX2LMNATSHRALOX12 | |
| SCHEMBL4538141 | 0.87 | BDKRB1 (0.46) | HSD11B1BDKRB1RAB9A | |
| SCHEMBL4543050 | 0.87 | BDKRB1 (0.52) | HSD11B1LMNAUSP2BDKRB1RAB9A | |
| SCHEMBL4537195 | 0.86 | HTR1A (0.50) | EPHX1EPHX2LMNAUSP2RAB9A | |
| SCHEMBL8064947 | 0.86 | HTR1A (0.50) | EPHX1EPHX2LMNAUSP2RAB9A | |
| SCHEMBL4537316 | 0.86 | LMNA (0.56) | EPHX1EPHX2LMNARAB9ATSHR | |
| SCHEMBL4542345 | 0.86 | EPHX2 (0.56) | EPHX1EPHX2RAB9A | |
| SCHEMBL4539653 | 0.85 | EPHX1 (0.46) | EPHX1EPHX2LMNATSHRALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |