Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539069 | 0.90 | ALDH1A1 (0.48) | KMT2AMEN1EPHX2LMNAALDH1A1 | |
| SCHEMBL8053633 | 0.86 | ALDH1A1 (0.43) | KMT2AMEN1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8048322 | 0.85 | ALDH1A1 (0.45) | KMT2AMEN1LMNAALDH1A1POLB | |
| SCHEMBL4530583 | 0.85 | EPHX2 (0.46) | KMT2AMEN1EPHX2LMNAALDH1A1 | |
| SCHEMBL4535853 | 0.85 | FBP1 (0.46) | KMT2AMEN1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4543002 | 0.85 | ALDH1A1 (0.45) | KMT2AMEN1LMNAALDH1A1POLB | |
| SCHEMBL4542247 | 0.85 | VCAM1 (0.52) | KMT2AMEN1LMNAALDH1A1MAPT | |
| SCHEMBL4542831 | 0.84 | ALDH1A1 (0.53) | KMT2AMEN1EPHX2LMNAALDH1A1 | |
| SCHEMBL4539837 | 0.83 | MEN1 (0.55) | KMT2AMEN1EPHX2LMNAALDH1A1 | |
| SCHEMBL4539846 | 0.83 | JAK2 (0.43) | LMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |