Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PAM | P19021 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4540058 | 0.92 | DGKA (0.42) | DGKADNM1CYP3A4TSHRATM | |
| SCHEMBL2881860 | 0.79 | ALDH1A1 (0.44) | DGKATSHRALDH1A1LMNAPAM | |
| SCHEMBL1147321 | 0.77 | DGKA (0.48) | DGKADNM1CYP3A4TSHRATM | |
| SCHEMBL249563 | 0.77 | DGKA (0.54) | DGKADNM1CYP3A4TSHRATM | |
| SCHEMBL247200 | 0.76 | DGKA (0.57) | DGKADNM1CYP3A4TSHRATM | |
| SCHEMBL494383 | 0.76 | DGKA (0.57) | DGKADNM1CYP3A4TSHRATM | |
| SCHEMBL494198 | 0.76 | DGKA (0.57) | DGKADNM1CYP3A4TSHRATM | |
| SCHEMBL494939 | 0.76 | DGKA (0.57) | DGKADNM1CYP3A4TSHRATM | |
| SCHEMBL249240 | 0.76 | DGKA (0.57) | DGKADNM1CYP3A4TSHRATM | |
| SCHEMBL494501 | 0.76 | DGKA (0.57) | DGKADNM1CYP3A4TSHRATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079440-B1 | TWO-COMPARTMENT SKINCARE PRODUCTS COMPRISING IVERMECTIN, AND USES THEREOF | GALDERMA SA (CH) | 2015-04-29 | — | — | EP | disclosed |
| US-8815938-B2 | Double compartment skincare products comprising avermectin/milbemycin compounds | GALDERMA S.A. (CH) | 2014-08-26 | — | — | US | disclosed |
| US-20090286866-A1 | Double compartment skincare products comprising avermectin/milbemycin compounds | GALDERMA S.A. (CH) | 2009-11-19 | — | — | US | disclosed |