Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PAM | P19021 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GSTK1 | Q9Y2Q3 | 2/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4540053 | 0.92 | DGKA (0.48) | DGKALMNATSHRALDH1A1PAM | |
| SCHEMBL2881860 | 0.87 | ALDH1A1 (0.44) | DGKALMNATSHRNFKB1PMP22 | |
| SCHEMBL536437 | 0.81 | DGKA (0.60) | DGKALMNATSHRNFKB1PMP22 | |
| SCHEMBL4209313 | 0.81 | DGKA (0.47) | DGKALMNATSHRNFKB1PMP22 | |
| SCHEMBL530468 | 0.81 | DGKA (0.47) | DGKALMNATSHRNFKB1PMP22 | |
| SCHEMBL29263455 | 0.79 | DGKA (0.50) | DGKALMNATSHRNFKB1PMP22 | |
| SCHEMBL1258235 | 0.79 | MAPT (0.47) | DGKALMNATSHRNFKB1PMP22 | |
| SCHEMBL27842955 | 0.79 | DGKA (0.50) | DGKALMNATSHRNFKB1PMP22 | |
| SCHEMBL8652099 | 0.79 | DGKA (0.50) | DGKALMNATSHRNFKB1PMP22 | |
| SCHEMBL3194001 | 0.79 | LMNA (0.55) | DGKALMNATSHRNFKB1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079440-B1 | TWO-COMPARTMENT SKINCARE PRODUCTS COMPRISING IVERMECTIN, AND USES THEREOF | GALDERMA SA (CH) | 2015-04-29 | — | — | EP | disclosed |
| US-8815938-B2 | Double compartment skincare products comprising avermectin/milbemycin compounds | GALDERMA S.A. (CH) | 2014-08-26 | — | — | US | disclosed |
| US-20090286866-A1 | Double compartment skincare products comprising avermectin/milbemycin compounds | GALDERMA S.A. (CH) | 2009-11-19 | — | — | US | disclosed |