Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN1 | O60741 | 10/20 | 0.44 |
| ▸ | HCN4 | Q9Y3Q4 | 12/20 | 0.42 |
| ▸ | HCN3 | Q9P1Z3 | 1/20 | 0.42 |
| ▸ | HCN2 | Q9UL51 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13706601 | 1.00 | HCN1 (0.44) | HCN1HCN4HCN3HCN2ALDH1A1 | |
| SCHEMBL13706822 | 0.91 | HCN1 (0.42) | HCN1HCN4HCN3HCN2ALDH1A1 | |
| SCHEMBL4364179 | 0.91 | P2RX7 (0.48) | HCN1HCN4HCN3HCN2ALDH1A1 | |
| SCHEMBL13706815 | 0.91 | P2RX7 (0.48) | HCN1HCN4HCN3HCN2ALDH1A1 | |
| SCHEMBL4358058 | 0.91 | HCN1 (0.42) | HCN1HCN4HCN3HCN2ALDH1A1 | |
| SCHEMBL13706899 | 0.91 | P2RX7 (0.48) | HCN1HCN4HCN3HCN2ALDH1A1 | |
| SCHEMBL4527646 | 0.89 | HCN4 (0.42) | HCN1HCN4HCN3HCN2ALDH1A1 | |
| SCHEMBL4531164 | 0.86 | P2RX7 (0.46) | HCN1HCN4HCN3HCN2P2RX7 | |
| SCHEMBL4355954 | 0.85 | HCN1 (0.62) | HCN1HCN4ALDH1A1TSHRP2RX7 | |
| SCHEMBL13706805 | 0.84 | P2RX7 (0.41) | HCN1HCN4HCN3HCN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108551-A2 | HETEROARYL AMIDE ANALOGUES | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | claimed |