Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537833 | 0.97 | RAB9A (0.48) | ALDH1A1L3MBTL1HTR7LMNATRPA1 | |
| SCHEMBL4541024 | 0.90 | RAB9A (0.48) | L3MBTL1LMNAFKBP1ARAB9AEPHX1 | |
| SCHEMBL4542928 | 0.90 | LMNA (0.55) | ALDH1A1LMNAFKBP1ATSHREPHX1 | |
| SCHEMBL4542819 | 0.89 | RAB9A (0.54) | FKBP1ARAB9AEPHX1NPC1 | |
| SCHEMBL4541345 | 0.88 | POLB (0.44) | ALDH1A1L3MBTL1HTR7LMNARAB9A | |
| SCHEMBL4542205 | 0.87 | RAB9A (0.52) | RAB9ANPC1 | |
| SCHEMBL8062139 | 0.87 | RAB9A (0.43) | ALDH1A1L3MBTL1HTR7LMNATRPA1 | |
| SCHEMBL4540868 | 0.87 | BDKRB1 (0.49) | ALDH1A1RAB9ATSHREPHX1MAPT | |
| SCHEMBL4541294 | 0.87 | PSEN1 (0.56) | ALDH1A1LMNAFKBP1ATSHREPHX1 | |
| SCHEMBL4537242 | 0.86 | NPC1 (0.53) | ALDH1A1FKBP1ARAB9AEPHX1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |