Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542153 | 0.97 | ALDH1A1 (0.47) | RAB9AALDH1A1L3MBTL1MAPTTDP1 | |
| SCHEMBL4540868 | 0.90 | BDKRB1 (0.49) | RAB9AALDH1A1MAPTTSHREPHX1 | |
| SCHEMBL4541294 | 0.90 | PSEN1 (0.56) | ALDH1A1MAPTLMNATSHREPHX1 | |
| SCHEMBL8062139 | 0.90 | RAB9A (0.43) | RAB9AALDH1A1L3MBTL1MAPTTDP1 | |
| SCHEMBL4537242 | 0.90 | NPC1 (0.53) | RAB9AALDH1A1NPC1SMN1; SMN2EPHX1 | |
| SCHEMBL4539776 | 0.89 | BRD4 (0.53) | ALDH1A1LMNAEPHX1 | |
| SCHEMBL4535199 | 0.87 | MMP1 (0.53) | RAB9ANPC1 | |
| SCHEMBL4541024 | 0.87 | RAB9A (0.48) | RAB9AL3MBTL1LMNAEPHX1 | |
| SCHEMBL4542928 | 0.87 | LMNA (0.55) | ALDH1A1LMNATSHREPHX1PSEN1 | |
| SCHEMBL4542819 | 0.86 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |