Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541294 | 0.97 | PSEN1 (0.56) | LMNATSHRHTTNPSR1ALOX12 | |
| SCHEMBL4541024 | 0.90 | RAB9A (0.48) | LMNAEPHX2HPGDBDKRB1FKBP1A | |
| SCHEMBL4542153 | 0.90 | ALDH1A1 (0.47) | LMNATSHRHTTNPSR1ALOX12 | |
| SCHEMBL4542819 | 0.89 | RAB9A (0.54) | EPHX2FKBP1AEPHX1 | |
| SCHEMBL4536998 | 0.88 | BDKRB1 (0.49) | LMNATSHRHTTNPSR1ALOX12 | |
| SCHEMBL8060066 | 0.87 | PSEN1 (0.50) | LMNATSHRHTTNPSR1ALOX12 | |
| SCHEMBL4542205 | 0.87 | RAB9A (0.52) | BDKRB1PAX8HCRTR1HCRTR2 | |
| SCHEMBL4540868 | 0.87 | BDKRB1 (0.49) | TSHRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4537833 | 0.87 | RAB9A (0.48) | LMNATSHRHTTNPSR1ALOX12 | |
| SCHEMBL4537242 | 0.86 | NPC1 (0.53) | EPHX2ALDH1A1BDKRB1FKBP1AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |