Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | USP5 | P45974 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4534659 | 0.90 | CYP3A4 (0.53) | TGM2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL4539523 | 0.90 | ALDH1A1 (0.50) | TGM2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL4538137 | 0.89 | LMNA (0.48) | TGM2ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL4535273 | 0.89 | HTT (0.51) | HTTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL4542881 | 0.88 | KMT2A (0.46) | TGM2HTTALDH1A1MEN1KMT2A | |
| SCHEMBL4541028 | 0.85 | MEN1 (0.52) | HTTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL4541778 | 0.85 | LMNA (0.58) | HTTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL4541327 | 0.84 | HDAC3 (0.51) | — | |
| SCHEMBL4541252 | 0.82 | EPHX2 (0.50) | TGM2HTTALDH1A1MEN1KMT2A | |
| SCHEMBL4537553 | 0.81 | PAX8 (0.58) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |