Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 6/20 | 0.54 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6451494 | 0.89 | KDM4E (0.58) | KDM4EHTTTLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL4563112 | 0.82 | NPC1 (0.56) | KDM4EHTTTLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL1147702 | 0.82 | KDM4E (0.73) | KDM4EHTTTLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL4229962 | 0.82 | TERT (0.63) | KDM4EHTTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4218154 | 0.80 | CA1 (0.65) | KDM4EHTTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4223765 | 0.80 | TLR7 (0.60) | KDM4ETLR7ALDH1A1L3MBTL1MAPT | |
| SCHEMBL6450640 | 0.78 | KDM4E (0.60) | KDM4EHTTTLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL6449069 | 0.78 | RAB9A (0.62) | KDM4EHTTTLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL9725157 | 0.77 | NPC1 (0.68) | KDM4ESMN1; SMN2L3MBTL1NPC1PKM | |
| SCHEMBL12894824 | 0.76 | KDM4E (0.54) | KDM4EHTTTLR7ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026248-A2 | HYDRAZIDE, AMIDE, PHTHALIMIDE AND PHTHALHYDRAZIDE ANALOGS AS INHIBITORS OF RETROVIRAL INTEGRASE | THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER (US) | 2009-02-26 | — | — | WO | claimed |